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Medical Microbiology – Book

Pathogenesis and clinical pictures. Humans show considerable resistance to P. carinii infections, which explains why about two-thirds of the populace are either carriers or have a history of contact with the organism. The disease only becomes manifest in the presence of defects in the cellular immune system.

Of primary concern among the clinical manifestations is interstitial pneumonia. The profuse proliferation of the pathogen in the alveoli damages the alveolar epithelium. The pathogens then penetrate into the interstitium, where they cause pneumonia.